NEMBUTAL® Sodium Solution
(pentobarbital sodium) Injection, USP
DO NOT USE IF MATERIAL HAS PRECIPITATED
The barbiturates are nonselective central nervous system depressants which are primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section).
Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.
WHAT IS NEMBUTAL?
NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. Factors of consideration are the patient’s age, weight, and condition. Use parenteral routes only when oral administration is impossible or impractical.
Make IM injection of the sodium salts of barbiturates get deeply into a large muscle, and a volume of 5 mL is the limit at any one site because of possible tissue irritation. After IM injection of a hypnotic dose, monitor the patient’s vital signs so as to avoid any unusual situation. The usual adult dosage of NEMBUTAL (pentobarbital) Sodium Solution is 150 to 200 mg as a single IM injection; the pediatric dosage ranges from 2 to 6 mg/kg as a single IM injection not to exceed 100 mg.
NEMBUTAL IV injection don’t get along with conditions in which other routes are not feasible, either because the patient is unconscious (as in cerebral hemorrhage, eclampsia, or status epilepticus), or because the patient resists (as in delirium), or because prompt action is imperative. Slow IV injection is essential, and patients have to be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available.
The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium. The possibility of overdose and respiratory depression is remote when the drug is injected slowly in fractional doses. A commonly used initial dose for the 70 kg adult is 100 mg. . At least one minute is necessary to determine the full effect of intravenous pentobarbital. This is one of the most intriguing meds you will ever come across
1 gram, 10 grams, 2 grams, 5 grams